Influence of glicoregulation and chronic degenerative complications of diabetes on bone mineral density
M. Džeba, , A. Kovačić
Medical Faculty, University of Novi Sad, Serbia

Aim: The aim of this study is to determine the correlation between duration of diabetes, glicoregulation and chronic degenerative complications of diabetes, on one side, and bone mineral density, on the other side.

Introduction: Diabetes mellitus is a state of chronic hyperglycaemia. In late stages of the disease, especially if it is not regulated well, chronic complications may occur, dominating the clinical picture. Osteoporosis is characterized by bone loss per volume unit leading to microarchitectonics disorder of the bone. Connection between diabetes and osteoporosis is very complex.

Methods: Medical documentation collected at daily hospital of Clinic of endocrinology, diabetes and metabolic disorders is used in this study. Sample includes 60 patients which have been diagnosed with diabetes mellitus, with or without complications, who underwent densitometry measurement (DEXA). Glycosylated hemoglobin (HbA1c), fasting glucose and postprandial glucose are used as parameters of glicoregulation.

Results: Average duration of diabetes is 15.61±9.63 years. Average value of HbA1c is 8.5±1.79%, average value of fasting glucose is 9.23±2.94mmol/l and average value of postprandial glucose is 11.35±4.27mmol/l. 67% of patients have one or more complications. Bone mineral density (g/cm2) of femoral neck and total have significant negative correlation with HbA1c (p??0.01). Bone mineral density of lumbosacral spine and femoral neck (g/cm2, T-score) have light negative correlation with postprandial glucose.

Conclusion: Bone mineral density and parameters of glicoregulation have negative correlation. Statistically significant correlations between bone mineral density and chronic degenerative complications of diabetes were not found.

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