The path toward an HIV-1 vaccine
Fernando Garces
Therapeutic Discovery, Amgen, Inc., CA, United States
Received 10 June 2017, Accepted 15 June 2017

HIV is responsible for millions of deaths around the world and in the absence of available treatment capable of a cure, only the vaccine can offer protection against this virus. However, and after three decades of research, such a vaccine remains elusive. Here, I attempt to explain the major challenges on the development of an anti-HIV immunogen, and how the three-dimensional pictures of antibodies interacting with this virus can guide us to the design of a successful vaccine.

HIV-1 virus, Vaccine, HIV-1 trimer structures, Immunogen design, HIV-1 antibodies

Open Access

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Porto Biomedical Journal is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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