Original article
The acute effect of the antioxidant drug “U-74389G” on mean platelet volume levels during hypoxia reoxygenation injury in rats
C. Tsomposa,, , C. Panoulisb, K. Toutouzasc, A. Triantafylloud, G. Zografosc, A. Papaloise
a Department of Obstetrics & Gynecology, Mesologi County Hospital, Etoloakarnania, Greece
b Department of Obstetrics & Gynecology, Aretaieion Hospital, Athens University, Attiki, Greece
c Department of Surgery, Ippokrateion General Hospital, Athens University, Attiki, Greece
d Department of Biologic Chemistry, Athens University, Attiki, Greece
e Experimental Research Centre ELPEN Pharmaceuticals, S.A. Inc., Co., Pikermi, Attiki, Greece
Received 02 April 2016, Accepted 06 October 2016
Abstract
Background

This experimental study examined the effect of the antioxidant drug “U-74389G”, on a rat model and particularly in a hypoxia – reoxygenation protocol. The effects of that molecule were studied hematologically using blood mean platelets volume (MPV) levels.

Methods

40 rats of mean weight 231.875g were used in the study. MPV levels were measured at 60min of reoxygenation (groups A and C) and at 120min of reoxygenation (groups B and D). The drug U-74389G was administered only in groups C and D.

Results

U-74389G administration kept significantly increased the predicted MPV levels by 12.77±3.07% (p=0.0001). Reoxygenation time non-significantly decreased the predicted MPV levels by 2.55±3.71% (p=0.4103). However, U-74389G administration and reoxygenation time together kept significantly increased the predicted MPV levels by 7.09±1.91% (p=0.0005).

Conclusions

U-74389G administration whether it interacted or not with reoxygenation time kept significantly increased the predicted MPV levels. This finding has great clinical interest in blood clotting and coagulation pathophysiology.

Keywords
Hypoxia, U-74389G, Reoxygenation, Mean platelets volume

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