This experimental study examined the effect of the antioxidant drug “U-74389G”, on a rat model and particularly in a hypoxia – reoxygenation protocol. The effects of that molecule were studied hematologically using blood mean platelets volume (MPV) levels.Methods
40 rats of mean weight 231.875g were used in the study. MPV levels were measured at 60min of reoxygenation (groups A and C) and at 120min of reoxygenation (groups B and D). The drug U-74389G was administered only in groups C and D.Results
U-74389G administration kept significantly increased the predicted MPV levels by 12.77±3.07% (p=0.0001). Reoxygenation time non-significantly decreased the predicted MPV levels by 2.55±3.71% (p=0.4103). However, U-74389G administration and reoxygenation time together kept significantly increased the predicted MPV levels by 7.09±1.91% (p=0.0005).Conclusions
U-74389G administration whether it interacted or not with reoxygenation time kept significantly increased the predicted MPV levels. This finding has great clinical interest in blood clotting and coagulation pathophysiology.