Review article
Statins as anti-inflammatory agents: A potential therapeutic role in sight-threatening non-infectious uveitis
Rose Gilberta,b,, , Ahmed Al-Janabia,b, Oren Tomkins-Netzera,b, Sue Lightmana,b
a Moorfields Eye Hospital, London, UK
b University College London (UCL) Institute of Ophthalmology, London, UK
Received 05 October 2016, Accepted 05 January 2017
Abstract

In addition to the known lipid-lowering effects, statins are now widely accepted to have anti-inflammatory and immunomodulatory effects. Adjunctive use of statins has proven beneficial in the context of a wide range of inflammatory diseases, including rheumatoid arthritis. Evidence also suggests that statins may also have utility in the management of uveitis, a form of sight threatening inflammation which occurs in the eye. In this article, we outline our rationale behind a clinical trial of simvastatin as a steroid-sparing agent in uveitis, to which patient recruitment started last year. Potential risks associated with the clinical use of statins, including putative effects on the eyes, are discussed.

Keywords
Uveitis, Statins, Ocular inflammatory disease, Steroid-sparing agents, Anti-inflammatory

Open Access

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