In addition to the known lipid-lowering effects, statins are now widely accepted to have anti-inflammatory and immunomodulatory effects. Adjunctive use of statins has proven beneficial in the context of a wide range of inflammatory diseases, including rheumatoid arthritis. Evidence also suggests that statins may also have utility in the management of uveitis, a form of sight threatening inflammation which occurs in the eye. In this article, we outline our rationale behind a clinical trial of simvastatin as a steroid-sparing agent in uveitis, to which patient recruitment started last year. Potential risks associated with the clinical use of statins, including putative effects on the eyes, are discussed.
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Statins as anti-inflammatory agents: A potential therapeutic role in sight-threatening non-infectious uveitis
Received 05 October 2016, Accepted 05 January 2017
Uveitis, Statins, Ocular inflammatory disease, Steroid-sparing agents, Anti-inflammatory