Rostrum
Role of platelets in immune system and inflammation
Ozge Sonmeza,, , Mehmet Sonmezb
a Istanbul University Cerrahpasa Medicine Faculty, English Medicine Programme, Istanbul, Turkey
b Karadeniz Technical University, School of Medicine, Department of Haematology, Trabzon, Turkey
Received 26 January 2017, Accepted 31 May 2017
Abstract

Platelets have significant role in modulating clot formation. Additionally, emerging data indicates that platelets have considerable roles in inflammation and immune response. Platelets gather at the damaged cite and adhere to white blood cells. Subsequently, they release cytokines and chemokines which are chemotactic for neutrophils and monocytes. Therefore, platelets are necessary for targeting lymphocytes, neutrophils and monocytes to inflammation site. Those interactions enhance inflammation. Moreover, platelets serve as an immune cell by engulfing microbes. Presence of platelets affect prognosis in some bacterial or viral infection and several other diseases.

Keywords
Platelets, Immune system

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